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Benson Hill Receives Patent for Novel CRISPR Technology

By Benson Hill

February 20, 2018

Novel Cms1 CRISPR Nuclease Portfolio Available to Partners to Drive Crop Improvement


ST. LOUIS, MO—February 20, 2018— The U.S. Patent and Trademark Office has granted Benson Hill Patent No. 9,896,696 related to CRISPR 3.0 Cms1 genome editing nucleases, further expanding the company’s suite of genomics tools to accelerate crop performance improvements.

Benson Hill’s genome editing system Edit, powered by CropOS™, enables companies across the agri-food value chain to tap natural genetic diversity as a powerful source of product differentiation to improve the health and sustainability of our food system.  This patent validates the novelty of Benson Hill’s CRISPR 3.0 nuclease sequences and their usefulness as an alternative genome editing solution for organizations interested in accessing this technology to accelerate their business goals.


“Benson Hill is dedicated to delivering highly efficient and fully accessible product development solutions for our partners. We’re excited about this first patent issuance relating to our CRISPR 3.0 nuclease portfolio, and we are excited to move forward with commercial and research applications of this technology.  We will continue to pursue filings for a pipeline of technologies and applications that provide choice, clarity and confidence to our partners.”
-Matt Crisp, CEO and co-founder of Benson Hill


The Edit system combines the analytical power of Benson Hill’s CropOS™ crop design platform with a robust portfolio of diverse genome editing nucleases to create the first comprehensive genome editing system.  Edit is designed to optimize plant characteristics such as flavor profiles, nutrient-density, and environmental sustainability with greater speed and precision than previously possible.


“Consistent with their commitment to empowerment and community, the Benson Hill team has proactively disseminated their CRISPR technologies for research purposes free of charge across academia. This confirmation of the novelty of the CRISPR 3.0 portfolio is an exciting development. It will provide the scientific community with access to a new genome editing technology that will continue to drive innovation to help solve some of the world’s greatest challenges.”
-Dr. Tom Brutnell, Director of the Enterprise Institute for Renewable Fuels at the Donald Danforth Plant Science Center and co-founder of Benson Hill


With this patent issuance, Benson Hill will further augment its focus on ease of use and accessibility for its partners.  The company will continue to make CRISPR 3.0 freely available for research purposes among the academic and not-for-profit communities and will further expand commercial product development opportunities with partners.  Click here to learn more about the benefits of the novel CRISPR 3.0 genome editing technology.

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